Facile Syntheses and Molecular - docking of Novel 2 substituted 3 , 4 - dimethyl - 1 H - pyrrole - 2 - carboxamide / 3 carbohydrazide analogues with Antimicrobial and 4 Antifungal properties 5

نویسندگان

  • Jitendra D. Bhosale
  • Rajesh Dabur
  • Gopal P. Jadhav
  • R. S. Bendre
چکیده

1 J.B and R.B.; School of Chemical Sciences, North Maharashtra University, Jalgaon – 425001. 7 2 R.D.; Department of Biochemistry, Maharshi Dayanand University, Rohtak –124 001. 8 3 G.J.; School of Medicine, Department of clinical & translational sciences, Creighton University, Omaha, NE, 9 68178, USA. 10 * Correspondence: [email protected]; Tel.: +1-408-359-0192 (G.J); [email protected] (R.B) 11

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Novel Linezolid like Analogues: Synthesis, Characterization and Biological Evaluation

The synthesis of 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one was achieved in two steps, In first step, pyrazine-2-carboxamide  dissolved in EtOH, 10% KOH solution with ClCH2COOH produced compound 2-(pyrazine-2-carboxamido) acetic acid (II) and in second step, compound (II) in (CH3CO)2O with aromatic aldehyde, and catalyst potassium ace...

متن کامل

Ionic Liquid-Promoted Synthesis of Novel Chromone-Pyrimidine Coupled Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study and Toxicity Study.

Herein, we report an environmentally friendly, rapid, and convenient ionic liquid ([Et₃NH][HSO₄])-promoted facile synthesis of ethyl 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 4(a-f) and 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidine-5- carbohydrazide derivatives 6(a-f). All the...

متن کامل

Substituted pyrazinecarboxamides: synthesis and biological evaluation.

Condensation of the corresponding chlorides of some substituted pyrazine-2-carboxylic acids (pyrazine-2-carboxylic acid, 6-chloropyrazine-2-carboxylic acid, 5-tert-butylpyrazine-2-carboxylic acid or 5-tert-butyl-6-chloropyrazine-2-carboxylic acid) with various ring-substituted aminothiazoles or anilines yielded a series of amides. The syntheses, analytical and spectroscopic data of thirty newly...

متن کامل

Design, Synthesis, Characterization and Antimicrobial Evaluation of Novel 2,4-Disubstituted Quinazoline Derivatives

Resistance to bacterial and fungal strains towards existing antimicrobial agents has become an increasing incietment for research and development of new molecules to guard them. Quinazoline ring system could be clubbed into many ring systems which lead to potent and highly active compounds. In this work, series of eighteen compounds were docked into the ecKAS III binding site (1HNJ, PDB ID) by ...

متن کامل

Synthesis and Biological Evaluation of Some Novel Triazole Derivatives

A series of eighteen novel 2-[(4-amino-5pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]-N-(substituted phenyl) propanamides 3(a-i) and 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl) thio]-N-(substituted phenyl) propanamides 5(a-i) were synthesized by reacting 4-amino-5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol (2) and 4-amino-5-phenyl-4H1,2,4-triazole-3-thiol (4) with the respective 2-chloro-N-(substituted ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2018